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Tumor-activated probe identifies metastases with spatial resolution To spatially detect the proteolytic activity in tissues, we designed a probe using the DNLGRAF substrate (MBvivo-DNLGRAF) that enables tissue retention of the probe upon cleavage through electrostatic interactions with a nearby cell membrane only after proteolytic activation (Fig

Annu Rev Pharmacol Toxicol 2009

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Enlist the help of department members who have the skills needed to implement the project, work to help members acquire any new skills necessary for the project, and obtain the necessary resources, which may include information, allocated time, space, and equipment