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Similarly, other studies using N G monomethyl-L-arginine (L-NMMA) in vivo infusion have ultimately found that the reduced smoking-related EDV was responsible for reduced NO production (42)

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From an implementation standpoint, physician-level identified barriers to smoking cessation include: Lack of time (70-78%) Lack of perceived patient motivation to quit smoking (44%) Lack of provider knowledge (42-56%) Lack of ancillary support (44%) Proposed solutions to these barriers include: Training for healthcare providers Designating dedicated cessation champions Follow-up support Structured programs and follow-up to increase quit rates Future implementation strategies in this space will include: Provider and patient education campaigns Clinical integration Incorporation into national bladder cancer guidelines Incorporation into bladder cancer therapeutic clinical trials Multidisciplinary collaboration Leads to higher success rates Increases cessation success by 25-35% Dr

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