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Ki-67, PCNA, p21, cyclin D1, and p53 were among the cell cycle and differentiated genes whose transcriptional and translational regulation was altered by nicotine [70]

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The report concluded that across the 12 EU agencies in the network, there were inevitable differences as to what constituted scientific uncertainty, depending on the type of data being used for scientific assessment for example, the difference between clinical or toxicological datasets as opposed to social science population studies

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