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Catenibacterium was also identified in another South African study with self-assessed PTSD symptoms (O'Hare et al., 2024), indicating potential geographic location-specific associations (Parizadeh and Arrieta, 2023)

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When applied during peak activity periods (nocturnal phase), VNS suppresses pro-inflammatory gene expression (e.g., IL-6), reduces inflammatory responses, and enhances BBB integrity through upregulation of ZO-1 and occluding (152, 158)

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