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Our findings are supported by the fact that ILC3 gene signatures are highly enriched in adult-onset asthma, which is often more severe than childhood-onset asthma and associates with a worse prognosis 46

and 19 smokers, ages 44 to 81, who had smoked a maximum of 116 pack years

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Cigarette smoking is one of the most common causes of lung diseases, including lung cancer and chronic obstructive pulmonary disease, and most demographic studies of COVID-19 patients have indicated that current smokers are at increased risk of severe infection and death