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To test these hypotheses, we used stable isotope methods to compare GSH synthesis rates and concentrations within erythrocytes, as well as plasma markers of oxidant damage, in adult patients with poorly controlled type 2 diabetes matched to nondiabetic control subjects

In all the models, dual SHP2/MEK inhibition or RAS inhibition increased lipid peroxidation, and GPX4 depletion frequently amplified this effect (Supplementary Fig

Obesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer

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