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Falsehood #5: NRT defeated cold turkey in clinical studies This might surprise you, but those wanting to stop smoking cold turkey have never been invited to compete in clinical trials against self-selecting smokers seeking months of free replacement nicotine, bupropion, or varenicline.[5] Unlike those going cold turkey, those seeking free "medicine" joined the study in hopes of diminishing their withdrawal syndrome, not quickly meeting, navigating, and moving beyond it