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Methadone's effects can last up to 24 hours, thereby permitting administration only once a day in heroin detoxification and maintenance programs

The long-term effects are well documented and include: Chronic lung diseases such as emphysema and chronic bronchitis Various cancers, including lung, mouth, throat, and bladder Cardiovascular disease and increased risk of heart attacks Stroke and damage to blood vessels Weakened immune function and delayed wound healing Smoking also harms nearly every organ in the body

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