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There is evidence that ancient civilizations in the Americas used organic tobacco plant medicinally and for spiritual ceremony 12,000 years ago

A Cochrane meta-analysis on 13 clinical studies involving HTPs concluded that there was moderate-certainty evidence that HTP users are exposed to lower levels of HPHCs than smokers

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According to a letter published in the New England Journal of Medicine, the vapor in e-cigs may contain up to 15 times the formaldehyde that's in regular tobacco-containing cigarettes