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10.1016/j.fct.2019.05.054 71

It is interesting to note that the Marlboro brand, famous for its macho Marlboro Man, was for decades a woman s cigarette (Mild as May with Ivory tips to protect the lips) before it underwent an abrupt sex change in 1954

Finally, people with a history of substance dependence are at higher risk for developing problematic use patterns, since nicotine acts on reward pathways that overlap with other addictions

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