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However, given the inconsistency and heterogeneity of findings, it can be inferred that the effects may vary between different UGT isoforms ( Nicotine, a well-known component of cigarette smoke, also alter metabolic pathways particularly by interfering with Organic Cation Transporters (OCTs) in vitro (Urakami et al., 1998
[158] A 2016 Cochrane review showed that the combination of medication and behavioural support was more effective than minimal interventions or usual care [159] and a 2019 review "suggests that neither reducing smoking to quit nor quitting abruptly results in superior quit rates