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PMID: 31921329 pubmed.ncbi.nlm.nih.gov/31921329

Mndel says all of this must be weighed at the societal level: These pouches might be the least harmful way of getting nicotine, especially compared to tobacco, but because theyre legal and so readily available, the high number of potential users is the big concern. Where Do We Go From Here

This is the most common, non-invasive way to treat both awake and sleep bruxism

Feng, Z

One study, for example, treated Sprague Dawley rats treated with gestational nicotine (3 mg/kg/day) and found that PNE offspring (P35/P36) had altered myelin expression of myelin-related transcription and trophic factors that produced alterations in myelin gene expression and oligodendrocyte functioning [165]