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In a randomized double-blind placebo-controlled trial conducted by Dichtel et al., adjunctive transdermal TST was not more effective than placebo in improving symptoms of depression among women with antidepressant-resistant major depression in 8-week treatment [37]

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These emotional side effects are a natural reaction to the absence of nicotine, which your brain has come to associate with stress relief, relaxation, and even happiness

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