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Abbreviations SGAC: Surgeon Generals Advisory Committee WHO: World Health Organization GATS: Global Adult Tobacco Survey FCTC: WHO Framework Convention on Tobacco Control HWLs: Health warning labels COPD: Chronic Obstructive Pulmonary Disease OR: Odds Ratio CI: Confidence Interval DAGs: Directed Acyclic Graphs SD: Standardized Deviation NCD: Non-communicable Diseases IQR: Interquartile Range ITC: International Tobacco Control References Surapong C, Piyapong J

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Figure 1 A flow chart diagram of the scoping review about the toxicity and health impact of IQOS with data from 20102021 We extracted information on the data source [independent, PMI, or other heated tobacco product (HTP) manufacturers] from each publications author affiliation, conflict of interest, and/or study funding sections