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As the researchers of the study explain, the findings in this large registry-based analysis support the existing literature on the association between smoking and TED and provide novel insight on the potential impact of smoking cessation on lowering the risk of surgical intervention for TED at the population-level. Echoing this sentiment, they further explain that smoking is described as a modifiable risk factor for TED proportionate to the number of cigarettes smoked a day, with a higher instance of ocular involvement in Graves disease patients who also smoke

17 Because many individuals use both e-cigarettes and traditional cigarettes, it may be difficult to determine the main etiology of oral lesions

Genetic variants also interact with hormone replacement therapy