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In cancer cells, TrxR1/2 inhibition by Hdy-7 induces cytotoxic autophagy through elevated ROS and TFEB activation, which can be reversed by antioxidants or p53 knockdown, illustrating the redox sensitivity of this pathway

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The use of serum-based circulating RNA was selected to enable repeated, non-invasive assessment of gut health-related nutrigenomic responses in working dogs, where intestinal tissue sampling is ethically and practically limited [88]