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FXR can regulate the synthesis of bile acids in a tissue-specific manner, regulating bile acid reabsorption, maintaining bile acid cycle homeostasis, and reducing cholesterol and fat production [186]

In order to adjust for biases that could be introduced by stratifying on smoking status, marginal structural models were used to estimate controlled direct effects of an index of socioeconomic disadvantage (incorporating household education, occupation and income) on vaping by smoking status (among adults and youth), adjusting for relevant confounders and for selection into smoking states

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