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These changes impair oxidative metabolism, which is essential for anti-inflammatory macrophage function, and may contribute to or result from the proinflammatory state, perivascular macrophages with elevated glycolytic capacity show enhanced transmigration in MS animal models and are associated with immune cell infiltration (59)

Dihexa is metabolised primarily by CYP3A4 enzymes, which oxidise the compound into inactive metabolites, and by UDP-glucuronosyltransferases, which conjugate it with glucuronic acid for renal excretion

Hubert, D