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Alterations to NAD + metabolism and/or decline in tissue NAD + levels are directly related to m -Dys and pathological conditions such as CVD 521

Further, increased expressions of liver PPAR- (peroxisome proliferator-activated receptors), which plays a vital role in decreasing triglycerides [57]

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639 As shown in Figure 12, 38% of Alzheimer's and other dementia caregivers indicate that the physical stress of caregiving is high to very high.A10 Dementia caregivers are 1.5 times more likely to indicate substantial physical difficulty providing assistance to their care recipients compared with nondementia caregivers

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