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Additionally, it outlines the FDA's regulatory efforts to reduce nicotine levels, the effects of nicotine on the body, and the role of Nicotine Replacement Therapies (NRTs) in managing nicotine dependence and withdrawal

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Epigenetic mechanisms, such as DNA methylation, RNA methylation, histone modification, exosomes (EXs), and non-coding RNA, with regulatory functions have been continuously revealed [41,42,43]

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