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However, demethylation of DNA also appears to be regulated by oxidative state, where oxidative stress sequentially hydroxylates 5-mC to 5-hmC, followed by successive oxidation to 5-formylcytosine and 5-carboxylcytosine, which would eventually lead to reduction of both 5-mC and 5-hmC levels [222, 227]

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However, they persevered and rented a warehouse in the city and were back at work within a month

Moreover, nicotine, a highly addictive substance, is deposited in the lung and rapidly absorbed, stimulating the central nervous system, and causing increase in heart rate and blood pressure [39, 40]