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It also identified several compounds in e-liquid that carry a risk of lung damage or disease, including: aldehydes, such as acetaldehyde and formaldehyde acrolein, a weed killer that may cause lung injury, COPD, and asthma diacetyl, which has links to severe lung diseases benzene, a component of car exhaust fumes Different smoking cessation tools are available, such as nicotine replacement therapy (NRT) in the form of gum or patches, counseling, and support services

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Conclusion This review summarized the current literature highlighting the negative effects of MDM2p53 axis dysfunction in the context of hepatoma cells transformation (Table 2)

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