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Materials and methods Data collection, study population, and selection criteria The data for this study were sourced from the GBD 2021 database ( This comprehensive database encompasses evaluation data for 204 countries and regions, covering 371 types of diseases and injuries, as well as 88 risk factors [12]

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Knockout of 7 nicotine receptors in mice resulted in decreased osteoclastogenesis, while circulating osteoprotegerin (OPG) was elevated, resulting in increased bone mass [54, 55]