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The overexpression of arginine methyltransferase 5 (PRMT5) in solid and hematological tumors leads to the elevation of the methylation level of arginine residues on functionally related proteins in tumor cells, which affects cell cycle regulation, mRNA splicing, cell differentiation, signal transduction, and other physiological processes

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Push the plunger all the way down, injecting that volume of air into the vial

For cells treated with ML226, a final concentration of 2.5 M was maintained throughout the assay to prevent washout

Funding No funds were received in support to this study