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Many infection-associated chronic illnesses are associated with POTS, including Lyme disease, long COVID, ME/CFS, and MS

Beyond orthopaedic applications, ozone therapy has shown potential in treating conditions such as chronic fatigue syndrome (CFS) and myalgic encephalomyelitis (ME) using different modalities such as ozonated water, ozone oil, and ozone gas [20,21,22,23,24]

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In addition, SARS-CoV-2 infection leads to the release of pro-angiogenic factors, such as vascular endothelial growth factor A (VEGF-A) (103)