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High-dose vitamin B12 supplements taken concurrently with the injection may lead to excessive B12 levels, though toxicity from vitamin B12 excess is extremely rare due to its water-soluble nature and efficient renal excretion
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Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71
