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Due to their potential properties related to cellular homeostasis, tissue regulation, and regenerative processes, they are at the heart of many preclinical research approaches

Details of the genetic analyses are available in the Supplementary Information

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Epitalon is a synthetic tetrapeptide studied in laboratory settings for its role in cellular ageing, telomere activity, and circadian rhythm regulation

FOXO4-DRI counteracts frailty and loss of renal function in naturally aged mice Encouraged by these results, we decided to challenge whether FOXO4-DRI could also target senescence and tissue homeostasis in normal mice that were allowed to age naturally