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Placental angiogenesis is crucial to maintain sufficient blood flow during gestation, and any alteration in this process may result in an adverse pregnancy [20]

Their work reveals the role of a transporter protein named SLC33A1 in shuttling oxidized glutathione (GSSG) across the ER membrane, a process vital for sustaining the oxidative environment necessary for correct protein folding

The Ox40/Ox40 ligand pathway promotes pathogenic Th cell responses, plasmablast accumulation, and lupus nephritis in NZB/W F1 mice

Therefore, cysteine is generally considered the rate-limiting step for endogenous glutathione production

It cycles between reduced (GSH) and oxidized (GSSG) forms to preserve cellular oxidative homeostasis