Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)
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In subcutaneous research protocols, doses of 1 to 4 mg per application are typically employed, with a frequency of 2 to 3 times per week
McConnell, H.L., Mishra, A., 2022
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