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Using the Luminex screening system, it was found that the serum concentration of C5a was significantly decreased in CHB patients with severe fibrosis and early liver cirrhosis [60]

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The central hypothesis of the gut-liver axis is that translocation of luminal microbiota or microbial products (pathogen-associated molecular patterns or PAMPs) through an impaired intestinal barrier function is an early step in the pathogenesis of chronic liver disease (4)

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