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After that, they can slowly go down to a lower maintenance dose

This oxidative insult has been demonstrated to impair pancreatic -cell function and exacerbate insulin resistance, thereby contributing to the progression of T2DM [310]

In addition, SREBP1c indirectly contributes to the development of hepatic insulin resistance, since enhanced lipogenesis and subsequent accumulation of harmful lipid species, such as diacylglycerides, may interfere with insulin signaling (as discussed below)

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Cellular nitric oxide production in vascular endothelial cells was detected by the emitted fluorescence from DAF-FM DA probe upon the interaction with nitric oxide