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This sequestration is important to remove the glutathione conjugate from the cytoplasm for several reasons including the instability of glutathione conjugates

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Acute and chronic GI disorders in humans and animal models are characterized by increased ROS production or decreased counteracting antioxidant mechanisms, both of which disrupt redox homeostasis (65)

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Glutathione plays a crucial role in several cellular and biochemical functions, including protecting cells from free radicals or detoxifying the body through the liver, as glutathione is present in every cell in the body, particularly in high concentrations in the liver