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The role of OS in ALS pathology, whether as a primary cause of disease or a secondary consequence, is now well recognized and many preclinical and clinical studies have consistently demonstrated that the disease is characterized by high levels of OS markers able to induce cellular damage, impaired cell signalling, and finally cell death [25, 86]

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24,25,26HYPOTHYROIDISMVitamin AActivates gene that regulates TSH(thyroid stimulating hormone)