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Also, it opposes the nowadays aggressive wound management if it considers in fistulas healing mostly local skin protection (Orangio, 2010

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Some more severe, but rare, side effects that can occur are low potassium levels, muscle cramps, irregular heartbeat, chest pains, or blurred vision

Secondary mechanisms include modulation of inflammatory cytokines and interaction with growth factor receptors, contributing to its broad regenerative profile in research models focused on musculoskeletal, gastrointestinal, and neural tissues

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