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FIGURE 1 2 The role of sleep in regulating free radicals in the brain: from Reimunds free radical flux theory to modern insights Reimunds free radical flux theory of sleep, proposed in the 1990s, received significant attention for suggesting that ROS accumulate in the brain during wakefulness, when energy consumption is high, and are subsequently cleared during sleep through a scavenging process that also suppresses their production (Reimund, 1994

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Fluorescence microscopy also confirmed that miniGrx1-roGFP2 localized appropriately to their respective targets and maintained functionality throughout the experiments ( Figure 2a )

The first follow-up review is usually at week four to six