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Phase 2 clinical trials for obesity were conducted but failed to meet primary weight loss endpoints

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The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison

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These unregulated versions may carry safety risks and impurities, and reduce their effectiveness