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Nrf2 mediates redox adaptations to exercise

Cell lysates were boiled for 15 min and protein concentration was determined by the Lowry method

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the expression of these proteins in the nucleus underscores the key role of glutathione in the regulation of the cell cycle and in chromosomal organization

The activation of CHAC1 by this pathway leads to increased apoptosis, as evidenced by its role in enhancing apoptosis markers such as TUNEL, PARP cleavage, and AIF nuclear translocation