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Vitamin A deficiency is a major public health problem in developing nations, where availability of foods containing preformed vitamin A (retinol) and provitamin A carotenoids is limited (for information on food sources of vitamin A, see the article on Vitamin A)

doi: 10.1016/j.steroids.2011.01.003

It interacts with multiple systems in the body including the nitric oxide (NO) pathway, growth hormone receptors, and angiogenic regulators like VEGF (vascular endothelial growth factor) to promote tissue repair, reduce oxidative stress, and modulate the immune response