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The US food and drug administration and probiotics: Regulatory categorization

Values are means SE

Increased intestinal permeability allows the translocation of harmful bacterial metabolites and antigens, such as lipopolysaccharide (LPS), from the intestinal lumen into the portal and systemic circulation

The standard body surface area scaling method, endorsed by the FDA for first-in-human dose estimates, typically divides the rodent dose by a factor of approximately 6.2 when converting from rat to human

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