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This underlying vulnerability explains why the pathological triggers of various neurodegenerative diseases can converge on ferroptosis in the aging brain

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Second, in PD, the abnormal aggregation of alpha-synuclein may increase excitotoxicity by affecting the transport efficiency of glutamate transporters and increasing the phosphorylation of NMDARs

Some early studies in animals have shown a potential risk to foetal development, which is why current advice is to avoid use in pregnancy and stop treatment well in advance of trying to conceive

The treatment is commonly available in subcutaneous injections, but alternative forms such as sublingual options have recently emerged