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Some contraindications (reasons not to take B12 shots) include: Allergies to cyanocobalamin or methylcobalamin Kidney or liver disease Eye issues, especially if you have Lebers disease A current infection If youre taking medication related to bone marrow You should talk to your doctor about the above conditions before getting B12 injections

Subcutaneous (SC) Injections Subcutaneous injections involve injecting B12 into the fatty tissue just beneath the skin

This will minimize your risk for unexpected reactions, that you might then blame on the B12 itself

Biotin is a water-soluble vitamin, therefore it is not easily stored in the body

No evidence of hormonal, hepatic, or systemic adverse effects has been observed in available data