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They have been shown to inhibit the production of IL-1, 2 and 6 and the phosphorylation of IkB kinase (IkappaB) (254), and thus the NF-kB signalling pathway

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This does not necessarily invalidate the GSSG:GSH ratio as a useful oxidative stress marker, because accumulation at sites such as the vacuole is predicted to be dependent on GSSG accumulation in other compartments caused by the oxidant-driven imbalance discussed above

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