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Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species

Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist

Bostock IC, Hofstetter W, Mehran R, Rajaram R, Rice D, Sepesi B, Swisher S, Vaporciyan A, Walsh G, Antonoff MB

In a rigorous clinical trial, the Southwest Oncology Group SWOG-8897 found that the MPO genotype of breast cancer patients undergoing chemotherapy was associated with a lower risk of recurrence, and a high-activity MPO genotype was related to a higher survival rate among women treated with cyclophosphamide [129]

Glutathione (GSH), a key regulator of oxidative stress and cellular immunity, has a critical role in modulating the functional states of CNS-resident and infiltrating immune cell subsets