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Treatment Frequency: Initially, injections are given 2 to 3 times per week

One of these studies demonstrated a 1.7-fold higher recovery of toxic metabolites in those with Gilberts syndrome compared to controls [33], although a larger study only found a higher rate of recovery of toxic metabolites in those patients stratified by having the lowest UGT activity [28]

10.1016/j.lfs.2022.120753 Life Sci

This metabolicimmune interplay not only reinforces therapeutic resistance but may also contribute to the establishment of a metabolic protective niche, providing a sanctuary within the multicellular tumor ecosystem that shields resistant subpopulations from treatment-induced stress

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