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In an open-label phase II trial, curcumin treatment (8 g/day) in combination with the anticancer drug gemcitabine was associated with severe abdominal pain in 7 out of 17 patients with advanced pancreatic cancer, leading to the treatment being discontinued in five patients while curcumin dosage was reduced to 4 g/day in two patients (79)

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239.) Available from: Vitamin B12, Fact Sheet for Health Professionals, National Institutes of Health, Office of Dietary Supplements Vitamin B12, Fact Sheet for Health Professionals, National Institutes of Health, Office of Dietary Supplements Homocysteine, Cleveland Clinic,

Flagg, J.C