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BPC-157's Regulatory History BPC-157 has had a turbulent regulatory journey in the United States: Pre-2023: BPC-157 was widely available through compounding pharmacies under the 503A framework

Vitamin B12 deficiency may cause numbness and tingling in the hands and feet, cognitive impairment, and reduced neurotransmitter production in the brain and spinal cord

Increased blood flow and pressure can worsen bruising, swelling, or make discoloration spread

It is not a drug, food, or cosmetic and may not be misbranded, misused, or mislabeled

As of February 2026 , BPC-157 returned to Category 1 compounding status meaning licensed 503A and 503B compounding pharmacies can legally prepare it under physician prescription