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PubChem CID: 9941957

There is some evidence that the diabetes drug metformin (Glucophage) may reduce vitamin B12 absorption when used for several years

The age-related drop in NAD+ levels is caused by rising levels of CD38, a membrane-bound NADase that degrades both NAD+ and its precursor nicotinamide mononucleotide, according to a 2016 study in mice, which exhibit age-related declines in NAD+ levels similar to those seen in humans (7)