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Although the exact mechanism of the connectivity of the gut-brain axis has not yet been elucidated, the evidence shows that gut microbiota plays an important role by producing immune factors, hormones, and metabolites that influence brain functioning

12 ] In humans, melatonin production often declines with age, which may contribute to sleep disturbances and disruptions in normal biological timing

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(2020) Nucleotides cytidine and uridine associated with vitamin B12 vs B-complex vitamins in the treatment of low back pain: the NUBES study

DOI: 10.3390/ph18020185