Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels
however, whether/how the equilibrium favors DUB degradation remains unclear 44,45
Mech Dev 59(2):129140 Cox CM et al (2006) Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo
Peptide synthesis for smaller molecules (5-29 amino acids) is far simpler than recombinant 191-amino-acid protein production
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