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Previous animal studies have also detected reduced Hcy concentrations after creatine supplementation ( Reference Taes, Delanghe and De Vriese 6 , Reference Stead, Au and Jacobs 20 )

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The urotoxicity of cyclophosphamide was studied and severe hemorrhagic cystitis in rats was observed with features of bladder enlargement, the occurrence of bleeding and increased levels of NO levels in urine as well as in plasma